Abstract

Solid dispersion approach with hydrophilic carriers is one of the most effective methods for improving the solubility, dissolution profile, and ultimately the oral bioavailability of poorly water-soluble drugs. In this study, Griseofulvin (GF), a BCS class II drug with poor solubility and a strong tendency to recrystallize, was formulated using hydrophilic polymers (HPMC E6, Polyvinylpyrrolidone K30 (PVP), and Soluplus) at drug to polymer ratios of 1:2, 1:3, and 1:4 using the solvent evaporation method. An experimental polymer-selection approach was employed to determine the optimal carrier type and ratio, wherein drug–polymer compatibility studies (FTIR), solid-state characterization (PXRD), saturated solubility studies, and dissolution behavior were systematically evaluated. The 1:3 HPMC formula demonstrated the most favorable performance, showing superior saturated solubility, enhanced dissolution rate, and good stability at harsh conditions across 90 days. This formulation represents a promising approach for improving the biopharmaceutical properties of Griseofulvin.